Research Summary - 2
Evaluation of 3-. 6-, and 9-Day Post-Treatment Intervals Following Pradofloxacin for Treatment of Bovine Respiratory Disease in Stocker Cattle
| Date/Time: |
9/12/2025
17:45
|
| Author: |
Lilli Heinen |
| Clinic: |
Kansas State University |
| City, State, ZIP: |
Manhattan, KS 66506 |
L. Heinen, DVM
1
;
B. Lubbers, DVM, PhD, DACVCP
1
;
R. Tessman, DVM, PhD, DACVIM, DACVPM
2
;
R. G. Amachawadi, BVSc, MS, PhD
1
;
B. White, DVM, MS
1
;
1Beef Cattle Institute, Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506
2Elanco Animal Health, Greenfield, IN, 46140
Introduction:
Pradofloxacin is a fluroquinolone antimicrobial approved for bovine respiratory disease
(BRD) treatment in cattle in the United States. Establishment of an appropriate post-treatment interval (PTI) following antimicrobial treatment for BRD should be made based on clinical outcomes. The study objective was to compare different PTIs following therapy with pradofloxacin on first treatment success, case fatality, and days to death in stocker cattle with naturally occurring BRD.
Materials and methods:
Cattle at five commercial stocker operations were identified with BRD by site personnel and were randomized to three PTI groups (3-, 6-, and 9-day) in a 1:1:1 ratio within cohorts. Following treatment with pradofloxacin, health outcomes were observed for 45 days. First treatment success is defined as no additional treatment for BRD and no mortality. Case fatality is defined as death due to any cause. Days to death measured the days from treatment to death in the mortalities. Generalized linear mixed models were used for statistical analysis and included weight and rectal temperature at treatment as fixed effects in addition to treatment.
Results:
There were no differences in first treatment success (p = 0.51), case fatality (p = 0.52), and days to death (p = 0.20) between PTI groups. Weight at treatment and rectal temperature were also not different between PTI groups.
Significance:
These results demonstrate no differences in outcomes between 3-, 6-, and 9-day PTIs and will assist with determining optimal use of pradofloxacin in stocker cattle.
